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Yet despite this commonality, we still know so little about why people develop migraine.
Researchers are still trying to determine the link between migraine and genetics.
Fortunately, this is changing.
But new studies are figuring out the link between migraine and genetics.
Why are researchers studying the link between genetics and migraine?
If someone can inherit the disorder from their family, the cause must at least partially come from genetics.
When investigating whether a trait is genetic, scientists look at its heritability.
National Library of Medicine.
The heritability estimates vary between the studies.
This makes it hard to detect patterns.
The exceptions are the rare forms of monogenic migraine, or migraine thats because of a single genetic variation.
The most well-known punch in of monogenic migraine is familial hemiplegic migraine (FHM).
A variation in the genes ATP1A2, CACNA1A, or SCN1A can each lead to FHM in an individual.
What are the hurdles in studying genetics and migraine?
Previously, this research has been done through genome-wide association studies (GWAS), Dr. Hautakangas explains.
What genes are linked to migraine?
It is the combined risk, in conjunction with environmental factors, that causes migraine.
Nonetheless, the research so far has revealed valuable information.
The most common migraine subtypes are migraine with aura (MA) and migraine without aura (MO).
(Some genetic variations are riskier than others.)
Why is knowing your family history helpful?
At the moment, this research is mostly useful for the scientific community.
However, understanding the role that genetics play in migraine can be helpful.
Additionally, these medications wont prove effective for everyone.
This could also be true for other forms of treatment, such as triptans.
Triptans, which are serotonin 5-HT1B/1D receptor agonists,6are one of the most common medications prescribed for people with migraine.
Of course, these theories should not replace doctor consultations.
What does the future look like for migraine and genetics research?
But that is the logical next step for migraine research and treatment.
Some drugs work well for some people but are ineffective for others.
